Protective Effect of Lipoic Acid on Oxidative Stress and Tissue Damage Induced by Aflatoxin B₁ in Young Laying Hens.

ABSTRACT: The aim of this study is to investigate the alleviating effect of lipoic acid on oxidative stress and tissue damage induced by aflatoxin B₁ (AFB₁) in young laying hens. The experiment was divided into a control group, an AFB₁ group, and three lipoic acid treatment groups. The AFB₁ group and three lipoic acid treatment groups were given diets supplemented with 90 μg/kg of AFB₁. The additional amounts of lipoic acid were 20, 100, and 500 mg/kg, respectively, with a feeding period of 4 weeks. The experimental results showed that AFB₁ significantly increased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and malondialdehyde (MDA) in the serum and significantly decreased

SUBMITTER: Chu Y 

PROVIDER: S-EPMC12031067 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature