Transcriptomics as an Early Warning of Domoic Acid Exposure in Pacific Razor Clams (<i>Siliqua patula</i>).

ABSTRACT: As oceans warm, harmful algal blooms (HABs) are expected to increase, including blooms of Pseudo-nitzschia, a diatom that produces domoic acid (DA), which is a potent neurotoxin. Regulatory limits for human consumption (0.075-0.1 mg/kg/day; acute exposure) exist for the Pacific razor clam; however, fisheries currently do not have regulatory limits for chronic low-level exposure to DA even though razor clams can retain DA for over a year after an algal bloom. For bivalves, exposure to marine toxins may disrupt important cellular processes, leading to concerns about effects on their overall health and potential population- and ecosystem-level impacts. Transcriptomics was used to identify differentially expressed genes in razor clams (N = 30) from Long Beach, WA, collected prior to, du

SUBMITTER: Bowen L 

PROVIDER: S-EPMC12031274 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature