Breaking the PRRSV-2 Life Cycle in Porcine Alveolar Macrophages: Tylvalosin's Multi-Stage Inhibition.

ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS) is one of the most serious diseases threatening the swine industry worldwide. However, no satisfactory control strategy has existed until now. In this study, the effectiveness of tylvalosin against PRRSV and the underlying mechanism was investigated. The results showed that in porcine alveolar macrophages (PAMs), tylvalosin can inhibit the replication of the NADC30-like and NADC34-like strains in a dose-dependent manner. It is worth noting that pre-incubation with tylvalosin had no significant inhibitory effect on the NADC30-like strain but did inhibit the NADC34-like strain. Co-incubation of both viruses and tylvalosin or post-incubation with tylvalosin after viral infection inhibited PRRSV. We further analyzed the effect of tylvalosin

SUBMITTER: An H 

PROVIDER: S-EPMC12031314 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature