Sulfatide Binds to Influenza B Virus and Enhances Viral Replication.

ABSTRACT: Seasonal influenza epidemics caused by influenza A viruses (IAV) and influenza B viruses (IBV) pose a substantial public health burden. Despite the significant impact of IBV, its restricted host range and the absence of documented pandemics have resulted in limited research attention relative to IAV. Understanding the viral infection mechanisms of both IAV and IBV is crucial for controlling seasonal epidemics. Previously, we demonstrated that 3'-O-sulfated galactosylceramide sulfatide binds to IAV and enhances viral replication, a finding with potential therapeutic implications. However, the role sulfatide plays in other influenza virus infections, including those caused by IBV, remains unknown. Accordingly, in this paper, we investigate the function of sulfatide during IBV infectio

SUBMITTER: Kurebayashi Y 

PROVIDER: S-EPMC12031359 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature