Ex Vivo Pharmacokinetic/Pharmacodynamic Integration Model of Cefquinome Against <i>Escherichia coli</i> in Foals.

ABSTRACT: Cefquinome is used to treat septicemia caused by Escherichia coli (E. coli) and respiratory infections caused by Streptococcus equi subsp. zooepidemicus in foals. However, studies reporting the use of cefquinome to target E. coli as pathogens of sepsis are lacking. Therefore, this study aimed to determine the optimal dosage regimen for cefquinome against E. coli using a PK/PD model. After the administration of 1 mg/kg cefquinome (intramuscularly or intravenously), blood samples were collected at different time points to determine the serum concentration of cefquinome via HPLC. The pharmacokinetic parameters were evaluated via NCA (WinNonlin 5.2.1 software). The main pharmacokinetic parameters of cefquinome in foals were as follows: after intravenou

SUBMITTER: Gao T 

PROVIDER: S-EPMC12031376 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature