Phage Endolysins as Promising and Effective Candidates for Use Against Uropathogenic <i>Escherichia coli</i>.

ABSTRACT: The presented in silico and phylogenetic analysis of putative endolysins potentially produced by phages infecting uropathogenic Escherichia coli (UPEC) demonstrates their remarkable diversity. These proteins exhibit significant variations in sequence length, molecular weight, isoelectric point, and stability, as well as diverse functional domains determining their enzymatic activity, including lysin, lysozyme, hydrolase, amidase, and peptidase functions. Due to their predicted lytic properties, endolysins hold great promise in combating UPEC bacteria, including those within biofilms, which are often highly resistant to conventional treatments. Despite their potential, several challenges hinder the full utilization of endolysins. These include the relatively small number of identifie

SUBMITTER: Wesolowski W 

PROVIDER: S-EPMC12031403 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature