Temporal Shift When Comparing Contrast-Agent Concentration Curves Estimated Using Quantitative Susceptibility Mapping (QSM) and ΔR2*: The Association Between Vortex Parameters and Oxygen Extraction Fraction.

ABSTRACT:

Background

When plotting data points corresponding to the contrast-agent-induced change in transverse relaxation rate from a dynamic gradient-echo (GRE) magnetic resonance imaging (MRI) study versus a corresponding spin-echo study, a loop or vortex curve rather than a reversible line is formed. The vortex curve area is likely to reflect vessel architecture and oxygenation level. In this study, the vortex effect seen when using only GRE-based estimates, i.e., contrast-agent concentration based on GRE transverse relaxation rate and contrast-agent concentration based on quantitative susceptibility mapping (QSM), was investigated.

Methods

Twenty healthy volunteers were examined using 3 T MRI. Magnitude and phase dynamic contrast-enhanced MRI (DSC-MRI) data were obtained using GR

SUBMITTER: Wirestam R 

PROVIDER: S-EPMC12031548 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature