HTLV-1 p13 Protein Hijacks Macrophage Polarization and Promotes T-Cell Recruitment.

ABSTRACT: The human T-cell leukemia type-1 (HTLV-1) retrovirus establishes chronic life-long infection in a fraction of infected individuals associated with severe pathological conditions. Although the mechanism driving disease development is not fully understood, current evidence indicates the essential functions of viral regulatory proteins. Among these, the p13 protein has previously been shown to localize to the inner mitochondrial membrane in T cells, altering mitochondrial biology and T-cell function. While CD4⁺ T cells are the primary cell target of HTLV-1 infection, genomic viral DNA has also been detected in monocytes, macrophages, and dendritic cells, which orchestrate innate and adaptive immunity and play a critical role in protecting against virus-induce diseases by establishi

SUBMITTER: Moles R 

PROVIDER: S-EPMC12031607 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature