Evaluation of the diagnostic value of a three-miRNA panel in prostate cancer: a discovery and validation study.

ABSTRACT:

Background

PSA is widely used in prostate cancer screening. However, false-positive PSA results can lead to misdiagnosis and wrong puncture biopsy, while false-negative PSA results can result in missed diagnosis and delayed treatment. There is an urgent need to find convenient, economical and non-invasive diagnostic methods to reduce the false-negative and false-positive rates of PSA. The aim of this study was to discover new miRNA panels to detect prostate cancer.

Materials and method

We selected 10 miRNAs in the literature that were associated with prostate cancer. Afterwards, we measured the expression levels of these miRNAs in serum of 112 prostate cancer patients and healthy controls through a training phase and a validation phase. By plotting receiver operating charact

SUBMITTER: Li X 

PROVIDER: S-EPMC12031705 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature