Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma.

ABSTRACT:

Purpose

Limited data from genome-wide association studies (GWAS) focusing on oral tongue squamous cell carcinoma (OTSCC) are available. The present study was conducted to explore genetic associations for OTSCC.

Methods

A GWAS on 376 cases of OTSCC was conducted using the FinnGen Data Freeze-12 dataset. The case-cohort included 205 males and 171 females. Cases with malignancies involving the base of the tongue or lingual tonsil were excluded from the case-cohort. Individuals with no recorded history of malignancy were used as controls (n = 407,067). A Phenome-wide association study (PheWAS) was performed for the lead variants to assess their co-associations with other cancers.

Results

GWAS analysis identified three genome-wide significant loci associated with OTSCC (p 

SUBMITTER: Nikkila R 

PROVIDER: S-EPMC12031715 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature