Kidney lipid metabolism: impact on pediatric kidney diseases and modulation by early-life nutrition.

ABSTRACT: Our review summarizes and evaluates the current state of knowledge on lipid metabolism in relation to the pathomechanisms of kidney disease with a focus on common pediatric kidney diseases. In addition, we discuss how nutrition in early childhood can alter kidney development and permanently shape kidney lipid and protein metabolism, which in turn affects kidney health and disease throughout life. Comprehensive integrated lipidomics and proteomics network analyses are becoming increasingly available and offer exciting new insights into metabolic signatures. Lipid accumulation, lipid peroxidation, oxidative stress, and dysregulated pro-inflammatory lipid mediator signaling have been identified as important mechanisms influencing the progression of minimal change disease, focal segmental glom

SUBMITTER: Nusken E 

PROVIDER: S-EPMC12031794 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature