EEG as a predictive biomarker of neurotoxicity in anti-CD19 CAR T-cell therapy.

ABSTRACT:

Objective

Immune effector cell-associated neurotoxicity syndrome (ICANS) is a potentially fatal complication of CD19-directed CAR T-cell therapy. The aim of this study was to investigate the role of EEG as a predictive biomarker of ICANS.

Methods

In this prospective, monocentric, cohort study, consecutive refractory B-cell non-Hodgkin lymphoma patients undergoing CAR T-cell therapy had EEG assessments at fixed time points pre- and post-infusion. The risk of ICANS was evaluated according to EEG findings detected qualitatively, using a grading scale ranging from 0 (normal) to 3 (severely abnormal), and quantitatively, using power spectral and connectivity measures.

Results

307 EEGs from 68 patients have been qualitatively evaluated, of whom 238 were eligible for quantit

SUBMITTER: Pondrelli F 

PROVIDER: S-EPMC12031834 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature