Comparison of Spinal Cord Regeneration Capacity in Zebrafish and Medaka.

ABSTRACT: In mammals, spinal cord injury often results in permanent impairment of motor function owing to ineffective tissue regeneration. Unlike mammals, zebrafish have the remarkable ability to regenerate many tissues, including the spinal cord. Cross-species comparison is an attractive approach for revealing regeneration-specific mechanisms, but the large evolutionary distance between species sometimes hinders direct comparison. Recent studies have revealed that another model fish species, medaka, has a low regenerative ability in some tissues, making comparisons with them advantageous to revealing regeneration-specific mechanisms. However, their spinal cord regenerative ability has not been compared to other models. In this study, we functionally and histologically compared the spinal cord regen

SUBMITTER: Aoki S 

PROVIDER: S-EPMC12031921 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature