ATP6AP1 drives pyroptosis-mediated immune evasion in hepatocellular carcinoma: a machine learning-guided therapeutic target.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains a major therapeutic challenge due to its immunosuppressive tumor microenvironment (TME) and resistance to immune checkpoint inhibitors (ICIs). Pyroptosis is a form of cell death with complex dual functions in tumor immunity. However, the precise regulatory mechanisms and interactions between pyroptosis and immune evasion in HCC remain poorly understood. This study aimed to elucidate the role of ATP6AP1 in pyroptosis-mediated TME remodeling and its potential as a therapeutic target.

Methods

We integrated large-scale datasets from TCGA and GEO databases to identify core modules by weighted gene co-expression network analysis (WGCNA), while mutation profiling and survival analysis verified clinical relevance. Multiple machine le

SUBMITTER: Tang L 

PROVIDER: S-EPMC12032091 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature