Photo-thermoresponsive polypyrrole-crosslinked single-chain nanoparticles for photothermal therapy.

ABSTRACT: Irradiating a chromophore allows cancer diagnostics by photoacoustic (PA) imaging, but also causes transformation of light into thermal energy and so enables therapy by photothermal effects. Useful chromophores for photothermal therapy (PTT), such as nanoconfined oligomers and polymers, should not only display an excellent light-to-heat efficiency, but in addition must display biocompatibility and good water-solubility. We in this study have designed water-dispersible, nanocaged polypyrroles (PPy), embedded into single-chain nanoparticles (SCNP, sized 6.8 - 8.9 nm) displaying thermoresponsivity, so reaching largely increased PTT-effects. Such encaged PPy-SCNPs allow an efficient photothermal heat conversion reaching temperatures up to 85°C. In a parallelized 96-well-plate-design the PPy-SC

SUBMITTER: Thummler JF 

PROVIDER: S-EPMC12032120 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature