Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.

ABSTRACT: Cognitive-behavioral therapy (CBT) is a primary treatment for depression. Although previous research has underscored the significant roles of white matter (WM) alterations and maladaptive parenting in depression risk, their associations with CBT response remain largely unknown. This longitudinal study investigated the interplay of WM integrity changes over time, treatment response, and parenting style in patients with depression. Diffusion-tensor-imaging and clinical data were assessed in n = 65 (55% female) patients with depression before and after 20 CBT sessions and n = 65 (68% female) healthy controls (HC) in a naturalistic design. Linear-mixed-effect models compared changes in fractional anisotropy (FA) between groups and tested associations between FA changes and symptom changes. It

SUBMITTER: Flinkenflugel K 

PROVIDER: S-EPMC12032135 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature