Integrated bioinformatics analysis screened the key genes and pathways of idiopathic pulmonary fibrosis.

ABSTRACT: To investigate the molecular mechanisms underlying idiopathic pulmonary fibrosis (IPF), we analyzed the GSE173355 and GSE173356 datasets obtained from the NCBI-GEO database. We identified differentially expressed genes (DEGs) and differentially methylated sites. Functional enrichment analysis was conducted for both DEGs and differentially methylated sites. Functional enrichment analysis was performed for both DEGs and differentially methylated sites, alongside an examination of immune-related scores, proportions, and GSVA enrichment scores of immune cells in IPF versus control samples. An integrated gene-methylation association analysis revealed 8 genes with expression levels negatively influenced by methylation. The Rap1 pathway, Focal adhesion, and Axon guidance were significantly enrich

SUBMITTER: Wu J 

PROVIDER: S-EPMC12032202 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature