CT radiomics from intratumor and peritumor regions for predicting poorly differentiated invasive nonmucinous pulmonary adenocarcinoma.

ABSTRACT: Per the 2021 World Health Organization (WHO) Classification of Thoracic Tumors, poorly differentiated invasive nonmucinous adenocarcinoma (INMA) demonstrates aggressive clinicopathological behavior characterized by lymphatic invasion, correlates with poor prognosis, and necessitates modifications to surgical planning even in early-stage adenocarcinoma. This study aimed to investigate the predictive value of radiomics features of intratumoral and peritumoral microenvironment in poorly differentiated INMA in the lung. A total of 451 patients with INMA were collected from three hospitals. They were divided into the train cohort (173 grade 1/2; 116 grade 3), internal test cohort (89 grade 1/2; 35 grade 3) and external test cohort (26 grade 1/2; 12 grade 3). The logistic regression analysis was

SUBMITTER: Duan L 

PROVIDER: S-EPMC12032246 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature