Identification and characterization of tissue resident memory T cells in malignant pleural effusions associated with non-small cell lung cancer.

ABSTRACT: Tissue resident memory T cells (TRM) play a critical role in cancer immunity and their presence in solid tumors is associated with improved prognosis and response to therapy. Although TRM have been identified and their function characterized in lung cancers, little is known regarding TRM outside of a tissue context, such as within malignant pleural effusions (MPE). As MPE are routinely drained and collected to manage symptoms, analysis of this fluid can provide an insight into the peri-tumoral environment. In this study, we performed flow cytometry and single cell RNAseq (scRNAseq) on MPE associated with non-small lung cancer and examined the phenotype and function of TRM. We found that 14% of CD8+ T cells and 6% of CD4+ T cells were TRM, as defined by the phenotype of CD45RO+CCR7-CD62L- a

SUBMITTER: Tilsed CM 

PROVIDER: S-EPMC12032394 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature