Treatment status, survival and gene expression analysis of large-cell neuroendocrine lung carcinoma: a real-world study in China.

ABSTRACT:

Background

Large-cell neuroendocrine lung carcinoma (LCNEC) is a rare subtype of lung cancer that lacks standard treatment at present.

Purpose

This study aimed to investigate the treatment status, failure pattern, survival outcome, and gene expression profile of LCNEC in China.

Design

This is a real-world retrospective study combined with transcriptome sequencing of LCNEC tumors.

Methods

Patients with newly diagnosed LCNEC at Beijing Chest Hospital from 2015 to 2022 were retrospectively reviewed. Treatment, failure pattern, and survival were analyzed. Transcriptome sequencing of LCNEC and non-small-cell lung cancer was conducted for differentiated expressed genes exploration and enrichment analysis.

Results

In all, 151 eligible patients met the criteria:

SUBMITTER: Qi F 

PROVIDER: S-EPMC12032454 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature