Associations between iron markers with hemoglobin and outcomes in peritoneal dialysis patients: results from the PDTAP study.

ABSTRACT:

Background and hypothesis

Iron metabolism markers, such as transferrin saturation (TSAT) and ferritin, are crucial in anemia management in patients with CKD and those undergoing dialysis, yet optimal levels remain unelucidated.

Methods

We conducted a prospective multicenter cohort study using data from the nationwide Peritoneal Dialysis Telemedicine-based Management Platform (PDTAP) to analyze TSAT, ferritin, and hemoglobin (Hb) levels, and their associations with mortality in the peritoneal dialysis (PD) population.

Results

Our study included 4429 PD patients, analyzing data through restricted cubic splines and Cox regression models, adjusted for multiple confounders. Non-linear associations between Hb levels and TSAT/ferritin were observed. Hb levels increased with

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12032523 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature