Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis.

ABSTRACT:

Background

The tissue- and developmental stage-specific expression of circular RNAs (circRNAs) makes them promising disease biomarkers. CircRNAs play a crucial role in regulating inflammatory responses; however, their function in canine parvovirus (CPV) infection remains largely unexplored.

Hypothesis

We hypothesized that circRNAs serve as biomarkers for disease severity, inflammation and organ damage in dogs with CPV.

Materials and methods

The study included six dogs with mild CPV, six with severe CPV and six healthy controls. Haematological and biochemical parameters were analysed from blood samples. CircRNA profiling in serum samples was conducted through high-throughput sequencing, followed by bioinformatic analysis to identify potential circRNA biomarkers. Associ

SUBMITTER: Degirmencay S 

PROVIDER: S-EPMC12032553 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature