INSTIs-centered antiviral regimens for first-line treatment of HIV/AIDS: a network meta-analysis and cost-effectiveness analysis.

ABSTRACT:

Objective

This study evaluates the efficacy, safety, and cost-effectiveness of INSTI-based antiretroviral regimens compared to the national standard first-line treatment EFV/3TC/TDF for HIV/AIDS in China. The aim is to guide clinical decision-making and improve HIV/AIDS prevention and treatment.

Methods

A network meta-analysis was conducted using ADDIS software on data from domestic and international randomized controlled trials comparing INSTI-based regimens with EFV/3 TC/TDF. Additionally, a Markov model assessed the cost-effectiveness of the representative INSTI regimen B/F/TAF (Bictegravir/Emtricitabine/Tenofovir Alafenamide) against EFV/3 TC/TDF. Costs and health outcomes were measured in US Dollars ($) and Quality-Adjusted Life Years (QALYs), respectively, evaluating i

SUBMITTER: Yang J 

PROVIDER: S-EPMC12032712 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature