First detection of HBV nucleic acid in the lung tissue of a patient with spontaneous recovery from HBV infection by tNGS: a case report.

ABSTRACT:

Background

After recovery from hepatitis B virus (HBV) infection, the virus is likely to reactivate once the body is in an immunosuppressed state. Currently, routine liver biopsies are difficult to obtain, and there are few reports on HBV nucleic acid detection in biopsies of other human organs and tissues. Targeted Next-Generation Sequencing (tNGS) can precisely focus on specific gene regions. Through high-throughput sequencing techniques, it can efficiently obtain a large amount of target nucleic acid sequence information and is widely applied in fields such as disease gene detection and tumor molecular diagnosis. With the development of tNGS, a new path has been opened for HBV nucleic acid detection in different organs, tissues and body fluids, offering hope to break through the

SUBMITTER: Zhenzhen L 

PROVIDER: S-EPMC12032778 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature