CHIRP-Seq: FOXP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes.

ABSTRACT:

Background

Vocal learning is a rare, convergent trait that is fundamental to both human speech and birdsong. The Forkhead Box P2 (FOXP2) transcription factor appears necessary for both types of learned signals, as human mutations in FOXP2 result in speech deficits, and disrupting its expression in zebra finches impairs male-specific song learning. In juvenile and adult male finches, striatal FOXP2 mRNA and protein decline acutely within song-dedicated neurons during singing, indicating that its transcriptional targets are also behaviorally regulated. The identities of these targets in songbirds, and whether they differ across sex, development and/or behavioral conditions, are largely unknown.

Results

Here we used chromatin immunoprecipitation followed by sequencing (ChIP-Seq

SUBMITTER: Gedman GL 

PROVIDER: S-EPMC12032786 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature