Dynamic phosphorylation of Fascin-1 orchestrates microglial phagocytosis and neurological recovery after spinal cord injury.

ABSTRACT: The persistence of myelin debris after spinal cord injury (SCI) constitutes a formidable barrier to axonal regeneration, remyelination, and functional recovery by initiating inflammatory cascades. Microglia, known for their superior phagocytic and degradative capabilities, are crucial in clearing myelin debris. Yet, the molecular mechanisms governing their function remain elusive. Our previous research has identified a sustained upregulation of Fascin-1, an actin-binding protein essential for phagocytosis, in Cx3cr1⁺ microglia after SCI. Here, we reveal that ablation of microglial Fascin-1 exacerbates neuronal loss and hampers motor recovery after SCI, correlating with diminished microglial phagocytic activity in Cx3cr1^cre+/-;Fascin-1^fl/fl mice. We demonstr

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12032802 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature