Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells.

ABSTRACT: Anticancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.

SUBMITTER: Liepe J 

PROVIDER: S-EPMC12032831 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature