IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages.

ABSTRACT:

Objective

Suppression of tumorigenicity 2 (ST2), the receptor for interleukin (IL)-33, has a critical role in tumor growth, angiogenesis, metastasis, and immune modulation. The IL-33/ST2 pathway is known to influence the polarization and function of macrophages, which is integral to modulating the tumor microenvironment. However, the precise role of IL-33/ST2 in tumors, particularly non-small cell lung cancer (NSCLC), has not been established.

Methods

ST2 expression in NSCLC was analysed using a murine model and patient specimens. The effect of the IL-33/ST2 axis on macrophage polarization in NSCLC was determined.

Results

Elevated ST2 expression was correlated with aggressive tumor growth. Specifically, ST2 expression on macrophages was associated with l

SUBMITTER: Liu L 

PROVIDER: S-EPMC12032832 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature