A blocking antibody against anti-Mullerian hormone restores ovulation and normal androgen levels in a spontaneous rat model of polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic Ovary Syndrome (PCOS), the leading cause of infertility worldwide, is characterised by oligo-anovulation, hyperandrogenism, polycystic ovarian morphology and high Anti-Müllerian hormone (AMH) levels, associated with severe metabolic disturbances. However, the role of AMH in the physiopathology of this syndrome remains poorly understood and strategies to block its effects have never been investigated in animal models of PCOS.

Methods

We used Western-blotting, ELISA and gene reporter approaches to evaluate the blocking efficacy, interspecificity and mechanism of action of an antibody against human AMH, Mab22A2. Then, we investigated the ability of a rat version of Mab22A2, rMab22A2, to alleviate reproductive dysfunction in Goto-Kakizaki (GK) rats, which s

SUBMITTER: Racine C 

PROVIDER: S-EPMC12032919 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature