Establishing the pig as a translational animal model for neurodevelopment.

ABSTRACT:

Background

Within the last few decades, the domestic pig has emerged as an advantageous biomedical animal model due to a vast number of similarities in realms of development and neuroanatomical features. Even so, a major challenge remains in how to translate time between the pig and human. Previously, researchers have developed a Translating Mammalian Time model that estimates the timing of 95 neurodevelopmental events across 9 mammalian species. By identifying the timing of these various events, one can include an additional animal into the model and assign a unique species score to predict the post-conception day (PCD) that other events will occur.

Objective

Our objective was to conduct a comprehensive literature review of pig neurodevelopmental events to enable chronologi

SUBMITTER: Sutkus LT 

PROVIDER: S-EPMC12032983 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature