P-Cymene inhibits pro-fibrotic and inflammatory mediators to prevent hepatic dysfunction.

ABSTRACT: This study evaluated the hepatoprotective potential of p-cymene (p-CYM) against two models of liver damage: ethanol (EtOH)-induced hepatocellular injury and diethylnitrosamine-carbon tetrachloride (DEN-CCl₄)-induced liver fibrosis (LF). HepG2 cells were treated with p-CYM or silymarin (SIL) before exposure to 10% EtOH in order to induce cellular injury. LF was induced in Sprague-Dawley rats using a single dose of DEN followed by increasing doses of CCl₄ over 60 days. Rats were treated twice weekly with p-CYM or SIL from day 21 to day 60. Results showed that p-CYM effectively mitigated EtOH-induced cell death in HepG2 cells by enhancing the activity of superoxide dismutase and glutathione reductase. In vivo findings revealed that p-CYM attenuated DEN- CCl_4<

SUBMITTER: Atif M 

PROVIDER: S-EPMC12032992 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature