Systolic blood pressure targets below 120 mm Hg are associated with reduced mortality: A meta-analysis.

ABSTRACT:

Background

The optimal systolic blood pressure (SBP) target in patients with increased cardiovascular risk remains uncertain. This study evaluated the efficacy and safety of intensive SBP control (<120 mm Hg) compared to standard SBP control (<140 mm Hg) in patients with increased cardiovascular risk.

Methods

We conducted a systematic search of PubMed, Embase, Web of Science, and Cochrane Library for RCTs published from database inception through November 2024 that compared intensive SBP control (<120 mm Hg) with standard SBP control (<140 mm Hg) in adults with high cardiovascular risk. Efficacy outcomes included all-cause mortality, major adverse cardiovascular events (MACE), cardiovascular death, stroke, myocardial infarction (MI), and heart failure. Safety outcomes includ

SUBMITTER: Bergmann F 

PROVIDER: S-EPMC12032999 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature