Increased risk of osteoporotic fractures and osteoporosis in patients with Addison's disease in Sweden: A nationwide population-based cohort study.

ABSTRACT:

Background

The risk of major osteoporotic fractures (MOFs) and osteoporosis in patients with autoimmune Addison's disease (AAD) is unclear.

Objective

To investigate the risk of MOF in patients with AAD and the possible correlation with adrenal hormone replacement doses.

Methods

Swedish national health registers were used to identify 1869 subjects with AAD and 16,844 matched controls. The primary outcome was MOF, and the secondary outcome was treatment with osteoporosis medications. Marginal Cox models were used to compare time-to-event outcomes. The study period spanned from 1 July 2005 until 31 December 2020. Individuals at risk were followed from inclusion until censored or the end of the study period.

Results

A total of 77 patients with AAD (7.1/1000 person-

SUBMITTER: Stergianos S 

PROVIDER: S-EPMC12033000 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature