Metabolic effects of high-dose glucocorticoid following out-of-hospital cardiac arrest.

ABSTRACT:

Background and aim

Patients resuscitated after out-of-hospital cardiac arrest (OHCA) face high morbidity and mortality rates, primarily due to ischemia-reperfusion injury, a complex metabolic disorder that triggers a significant systemic inflammatory response. Glucocorticoids mitigate inflammation but also impact the cells beyond the immune response. This study aims to identify glucocorticoid effects on plasma metabolites.

Methods

This explorative sub-study is part of a two-center, blinded, randomized controlled trial (NCT04624776) examining the effects of high-dose glucocorticoid on comatose patients resuscitated from OHCA of presumed cardiac origin. Following resuscitation, patients received 250 mg of methylprednisolone or a placebo in the prehospital setting. Blood sample

SUBMITTER: Beske RP 

PROVIDER: S-EPMC12033126 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature