Risk of Superficial Fungal Infections in WHIM Syndrome.

ABSTRACT:

Introduction

WHIM syndrome is a rare autosomal dominant inborn error of immunity caused by gain-of-function mutations in the chemokine receptor CXCR4. Patients with WHIM syndrome frequently suffer from an increased risk for bacterial and viral infections, especially warts due to human papillomavirus. Associations between WHIM syndrome and fungal infections have not been previously identified. The objective of this study was to estimate the prevalence of superficial fungal infections in patients with WHIM syndrome.

Methods

This retrospective single-institution cohort study assessed patients with genotype-confirmed WHIM syndrome evaluated between March 2007 and March 2024.

Results

Of 45 patients with WHIM syndrome, 18 (40%) were diagnosed with at least one superficial f

SUBMITTER: Strong J 

PROVIDER: S-EPMC12033133 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature