Early treatment monitoring of multidrug-resistant tuberculosis based on CT radiomics of cavity and cavity periphery.

ABSTRACT:

Background

Early identification of treatment failure can effectively improve the success rate of antituberculosis treatment. This study aimed to construct a predictive model using radiomics based on cavity and cavity periphery to monitor the early treatment efficacy in multidrug-resistant tuberculosis (MDR-TB).

Methods

We retrospectively collected data on 350 MDR-TB patients who underwent pretreatment chest computed tomography (CT) and received longer regimens from two hospitals. They were subdivided into training (252 patients from hospital 1) and testing (98 patients from hospital 2) cohorts. According to at least two consecutive sputum culture results within the early sixth months of treatment, patients were divided into high-risk and low-risk groups. Radiomics models wer

SUBMITTER: Lv X 

PROVIDER: S-EPMC12033146 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature