In Vitro and In Vivo Assessment of an Innovative Peeling System with Azelaic and Tranexamic Acids for Targeted Hyperpigmentation Reduction.

ABSTRACT:

Introduction

Melanin, derived from tyrosine, plays a pivotal role in skin pigmentation through melanogenesis. Disruptions in this process lead to hyperpigmentation, a condition affecting skin tone and quality of life. Current treatments, including chemical peels, have limitations, highlighting the need for novel solutions. Here, we present an innovative peeling system, comprising a masque and moisturizer, formulated with a novel blend of acids, including azelaic acid (AZA) and tranexamic acid (TXA), alongside known brightening and penetration-enhancing agents for a comprehensive solution to target hyperpigmentation.

Methods

In vitro studies assessed the ability of the novel moisturizer to inhibit ultraviolet-A (UVA)-induced melanin accumulation in human melanocytes. In a sin

SUBMITTER: Wong R 

PROVIDER: S-EPMC12033157 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature