Crotonylation deficiency of S100A7 K49 promotes psoriatic keratinocyte proliferation through enhanced interaction with RAGE.

ABSTRACT: Psoriasis is a chronic inflammatory dermatosis characterized by the hyperproliferative of keratinocytes. S100A7 plays a pivotal role in the pathogenesis of psoriasis. Lysine crotonylation of proteins is a newly identified modification that impacts diverse biological processes and its dysregulation has been implicated in autoimmune diseases. To investigate the profile of lysine crotonylation and its pathogenic role in psoriasis, we conducted a comparative analysis of crotonylation-modified proteins in psoriatic lesions versus healthy controls. Mutant keratinocytes with crotonylation deficiency of S100A7 were generated to explore its functional effects in psoriasis. Our omic analysis revealed a unique lysine crotonylation profile in psoriatic lesions, with a notable downregulation of crotony

SUBMITTER: Liang H 

PROVIDER: S-EPMC12033245 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature