Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice.

ABSTRACT: The prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, while treatment options are inadequate. Hypertension and obesity-related metabolic dysfunction contribute to HFpEF. Nitro-oleic acid (NO₂-OA) impacts metabolic syndromes by improving glucose tolerance and adipocyte function. Here we show that treatment with NO₂-OA ameliorates diastolic dysfunction and heart failure symptoms in a HFpEF mouse model induced by high-fat diet and inhibition of the endothelial nitric oxide synthase. Proteomic analysis of left ventricular tissue reveals that one-third of identified proteins, predominantly mitochondrial, are upregulated in hearts of NO₂-OA-treated HFpEF mice compared to naïve and vehicle-treated HFpEF mice. Increased mitochondri

SUBMITTER: Muller M 

PROVIDER: S-EPMC12033319 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature