Frailty, genetic predisposition, and incident chronic kidney disease.

ABSTRACT: Frailty is common among individuals with chronic kidney disease (CKD), whereas its impact on incident CKD risk remains unknown. This study aimed to prospectively evaluate the association between frailty and incident CKD risk, exploring the potential modification role of genetic risk factors (GRS). A cohort of 275,442 UK Biobank participants (mean age 55.3 ± 8.1 years, 43.4% male) without CKD were included. Physical frailty was defined by Fried Frailty phenotypes (FP) and Rockwood Frailty Index (FI). New-onset CKD was identified through hospital inpatient records and death register. GRS for CKD were calculated based on 27 single-nucleotide variants. Cox proportional hazards models and Fine-Gray competing risk models were applied to evaluate the hazard ratios (HRs) and 95% confidence interva

SUBMITTER: Zou S 

PROVIDER: S-EPMC12033349 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature