Metabolomic signatures of cognitive function in a type 2 Diabetes-Enriched cohort.

ABSTRACT: To understand the relationship between type 2 diabetes (T2D) and risk for developing cognitive impairment, this study is the first to examine association between metabolites measured at mid-life and cognitive performance assessed later in life (8-10 years) in a T2D-enriched cohort. The discovery set included metabolomics from European Americans (EAs; n = 137) and African Americans (AAs; n = 134) from the Diabetes Heart Study (DHS) and the African American-DHS (AA-DHS). The cognitive testing battery included measures of executive function, memory, attention, language, and global cognition. Ancestry-specific linear regression analyses were performed and a false discovery rate (FDR)-corrected p-value was used to assess significance. Overall, fewer significant metabolites were associated with

SUBMITTER: Powell J 

PROVIDER: S-EPMC12033351 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature