Profiling the LAM Family of Contact Site Tethers Provides Insights into Their Regulation and Function.

ABSTRACT: Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One such example is the LAM (Lipid transfer protein Anchored at Membrane contact sites) family in yeast, which is composed of six members, each containing a putative lipid binding and transfer domain and an ER-embedded transmembrane segment. The family is divided into three homologous pairs each unique in their molecular architecture and localization to different ER subdomains. However, what determines the distinct localization of the different LAMs and which specific roles they carry out in each co

SUBMITTER: Fenech EJ 

PROVIDER: S-EPMC12033502 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature