Screening of Germline BRCA1 and BRCA2 Variants in Nigerian Breast Cancer Patients.

ABSTRACT: BackgroundBreast cancer remains a leading cause of mortality among Nigerian women, with triple-negative breast cancer (TNBC) being particularly prevalent. Variations in BRCA1 and BRCA2 genes remain key risk factors for this disease. However, there are gaps in the frequency and spectrum of these variants in Nigerian populations, as well as a dearth in the local capacity to characterize these variations.ObjectiveThis study aimed at identifying and characterizing the germline variations in BRCA1/2 in Nigerian breast cancer patients and healthy age-matched controls to understand the genetic risk profile of breast cancer in this population.MethodsA prospective case-control study was conducted involving 45 breast cancer patients and 51 controls recruited from four major hospitals. DNA was extrac

SUBMITTER: Onyia AF 

PROVIDER: S-EPMC12033648 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature