The Barcelona baseline risk score to predict long-term prognosis after a first demyelinating event: a prospective observational study.

ABSTRACT:

Background

In multiple sclerosis (MS), predicting at symptom onset who will develop early and severe disability is an unmet need with significant therapeutic implications. Here we propose the Barcelona-Baseline Risk Score (BRS) model to predict long-term disease outcomes in a flexible and generalisable manner.

Methods

Using prospectively acquired data from the Barcelona first-attack cohort, we created the Barcelona-BRS model as a set of six Weibull survival models of time to an Expanded Disability Status Scale score of 3.0, built with flexible combinations of predictors, including sex, age at first attack, and number and topography of T2 lesions, among others, adaptable to data availability. Data-driven risk groups were identified and compared in terms of long-term clinical

SUBMITTER: Tur C 

PROVIDER: S-EPMC12033939 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature