Isolation and characterization of GI-19/L1148-like infectious bronchitis virus in China.

ABSTRACT: Ten infectious bronchitis viruses (IBVs) were isolated from diseased chicken flocks in China between 2018 and 2024. Phylogenetic, homology, and pairwise comparisons of the complete S1 gene revealed that the 10 isolates shared a close genetic relationship with the European L1148 vaccine strain. Complete genomic sequence of isolate I0317/22 confirmed this result. Inoculation of 1-day-old specific pathogen free (SPF) chickens with I0317/22 induced mild clinical signs. The virus replicated at low levels in most of the tissues, except in the respiratory and upper digestive (preventriculus) tracts. We speculate that the 10 isolates derived from the L1148 vaccine strain and spread with low pathogenicity within chicken flocks. In 1-day-old SPF chickens, inoculation with I0317/22 and vaccination wi

SUBMITTER: Li H 

PROVIDER: S-EPMC12033963 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature