Nanoscale piezoelectric patches preserve electrical integrity of infarcted hearts.

ABSTRACT: Ischemic heart disease is the leading cause of death worldwide. Several approaches have been explored to restore cardiac function, however few investigated new strategies to improve electrical functional recovery. Herein, we have investigated the impact of piezoelectric patches (Piezo patches), capable of generating electric charges upon mechanical deformation, on rat cardiac slices, healthy and ischemic hearts (ex vivo), on infarcted mice (in vivo) and on healthy and infarcted pigs (in vivo). Piezo patches did not preclude cardiac slice contractility, while compared with electrically inert control patches. In addition, Piezo patches showed an adequate safety profile in a working heart model as no electrophysiologic alterations were detected in healthy hearts. Epicardi

SUBMITTER: Monteiro LM 

PROVIDER: S-EPMC12033997 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature