Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.

ABSTRACT: Understanding sex differences in disease prevalence is critical to public health, particularly in the context of alcohol use disorder (AUD). The goal of this study was to understand sex differences in ethanol drinking behavior and define the precise conditions under which sex differences emerge. Consistent with prior work, C57BL/6J females drank more than males under continuous access two-bottle choice conditions. However, using ethanol self-administration - where an operant response results in access to an ethanol sipper for a fixed time period - we found no sex differences in operant response rates or ethanol consumption (volume per body weight consumed, as well as lick behavior). This remained true across a wide range of parameters including acquisition, when the ethanol sipper access p

SUBMITTER: Yoon HJ 

PROVIDER: S-EPMC12034132 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature