Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Background

Integrin glycosylation is one mechanism regulating the invasion and metastasis of malignant tumors. Little information exists about integrin glycosylation in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the glycosylation of integrins in HNSCC tumor and serum samples.

Methods

Intraoperative fresh tumor and normal tissue samples and blood samples were collected from HNSCC patients (N = 24). Lectin-bioaffinity assays using six nanoparticle-bound lectins were used to evaluate the glycosylation of integrins ITGA2, ITGA3, ITGA5, ITGA6, ITGB1, and ITGB4. Associations with metastasis, therapy response, and clinical factors were analyzed.

Results

Glycosylation profiles of the integrins were relatively similar. High intratumoral ITGB1-WF

SUBMITTER: Routila E 

PROVIDER: S-EPMC12034151 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature