Volumetric absorptive microsampling to measure iohexol and creatinine concentrations for estimation of glomerular filtration rate in cats: aligning animal welfare with practical feasibility.

ABSTRACT:

Background

Chronic kidney disease (CKD) is common in cats, and early detection is crucial for better prognosis. Currently, the gold standard to assess renal function is the measurement of glomerular filtration rate (GFR), allowing early detection of decreased kidney function. To overcome the practical limitations of this procedure, microsampling, collecting a small drop of blood from the cat's ear, can be used. Application of volumetric absorptive microsampling (VAMS) in feline nephrology would be of tremendous value, aligning with animal welfare and improving practical feasibility of GFR measurements.

Results

We developed and successfully validated liquid chromatography - tandem mass spectrometry (LC-MS/MS) methods to simultaneously determine iohexol and creatinine in plasm

SUBMITTER: De Baets H 

PROVIDER: S-EPMC12034177 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature