The chromatin reader Dido3 is a regulator of the gene network that controls B cell differentiation.

ABSTRACT: The development of hematopoietic cell lineages is a highly complex process governed by a delicate interplay of various transcription factors. The expression of these factors is influenced, in part, by epigenetic signatures that define each stage of cell differentiation. In particular, the formation of B lymphocytes depends on the sequential silencing of stemness genes and the balanced expression of interdependent transcription factors, along with DNA rearrangement. We have investigated the impact of Dido3 deficiency, a protein involved in chromatin status readout, on B cell differentiation within the hematopoietic compartment of mice. Our findings revealed significant impairments in the successive stages of B cell development. The absence of Dido3 resulted in remarkable alterations in the

SUBMITTER: Del Burgo FG 

PROVIDER: S-EPMC12034202 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature